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Rank 96Care Delivery

Plume

Offers digital, clinician-led gender-affirming hormone therapy and support services for transgender individuals.

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Signal Score
80.2
Total raised
$38M
Stage
Series B
Founded
2019
Headquarters
Denver, USA
Region
North America

Their signal

Plume has built a highly trusted virtual clinic that simplifies and secures life-saving gender-affirming care, backed by a clinical team deeply embedded in the community.

Signal Score 80.2editorial estimate, see how it is built
Capital (25% weight)76

Total raised, quality of investors and recency of the last round.

Growth (25% weight)80

Revenue trajectory, customer count, hiring and market pull.

Clinical & regulatory (20% weight)82

Peer-reviewed evidence, FDA/CE clearances and live health-system deployments.

Team (15% weight)84

Founder track record, clinical depth on the bench and technical leadership.

Online visibility (15% weight)81

Search presence, press coverage, founder and brand reach, and how often the company shows up where buyers look.

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